Endocrine Abstracts

Introduction: Acromegaly is a rare, progressive disease characterised by excess growth hormone. The recommended treatment is surgery. Radiotherapy and somatostatin analogues are used as adjuncts. The risk of post-radiotherapy osteosarcoma is 0.01% to 0.03% among all irradiated patients. We report a case of radiation-induced osteosarcoma that developed 22 years after radiotherapy for acromegaly.Case report: In 1997, a 53-year-old gentleman with acromegaly...

Long acting somatostatin analogues (SSA) such as Sandostatin LAR and Lanreotide Autogel are the most commonly used drugs in the management of neuroendocrine tumours (NETs) due to their ability to control symptoms and prolong survival. SSAs use is associated with changes in glucose metabolism. However, there is lack of data for such effects in patients with NETs. We evaluated the effects of SSA on BMI and HbA1c in our cohort of patients with NETs.Methods:...

Background: Bone is constantly remodelling and an imbalance between bone resorption and formation can predispose to osteoporosis. Bone turnover markers (BMTs) are biochemical markers that reflect the dynamics of bone formation and resorption. Carboxy-terminal collagen crosslinks (CTx) is a bone resorption marker measured in serum which is used to monitor treatment response.Aims: The aims of the study were to determine how CTx has been used to monitor pat...

Introduction: Most prolactinomas in females are diagnosed during the years of reproductive age and the majority are microadenomas. Prolactinomas diagnosed after menopause are very rare with limited published data on their presentation and outcomes.Aim: The aim of our study was to assess the presenting clinical, biochemical and imaging findings, as well as the outcomes of women diagnosed with a prolactinoma in the post-menopausal period.<p class="abst...

Background: Isolated pituitary stalk (PS) lesions/thickening detected on imaging pose challenging dilemmas.Aim: Audit the diagnostic approach and management of patients with isolated PS lesions/thickening reported on MRI in a tertiary hospital.Methods: Reports of pituitary/brain MRIs performed in our Radiology Department between 1/2013 and 12/2015 were searched for the terms ‘stalk’, ‘infundibular’, ‘infund...

Introduction: Clinically non-functioning pituitary adenoma (NFPA) represents up to 30% of pituitary tumours. Management is dictated by their size or mass effect. The natural progression of NFPA attracts debate as the evidence-base is limited.Methods: Conservatively managed NFPA patients were included. A single radiologist reviewed all images to avoid bias.Results: Forty-six patients were identified, 21 female. Four presented acutel...

Introduction: Incidental pituitary adenoma (IPA) is found in 10–20% autopsy and radiological series. These are being increasingly detected as access to sensitive imaging modalities improves.Methods: Patients with incidental pituitary findings between 2012 and 2016 were identified from local database. Referral details, clinical features and radiological findings were analysed. A single radiologist reviewed all images to avoid bias.<p class="abste...

Introduction: UK guidelines state that all patients undergoing adrenalectomy for phaeochromocytoma must be admitted to intensive care post-operatively due to the risk of haemodynamic instability (HDI). Intensive care beds are a scarce resource and it is important to regularly evaluate the need for admission, preventing unnecessary admission.Methods: The study population included all patients who underwent adrenalectomy for phaeochromocytoma at a UK terti...

Introduction: High incidence of polyp formation and mucosal hypertrophy in paranasal sinuses have been reported in patients with acromegaly. Lund-Mackay score is widely used to stage chronic rhinosinusitis.Aim: To assess changes in Lund-Mackay score after surgical or medical treatment of acromegaly and their relation to biochemical disease activity.Methods: Records of patients with paired (before and after treatment) pituitary/sinu...

A 61 year old female, without significant medical history, presented to her optometrist in Feb 2018 with clouding of vision and left sided proptosis. Opthalmic examination showed vision 6/7.5 right and 6/9 left eye, 3 mm proptosis on the left and diplopia on upward and right lateral gaze. Brain MRI demonstrated 6.3×5.6×5.8 cm lesion centered in the clivus and pituitary fossa, expanding in all directions; the bulk of the lesion was in the left parasellar region, encas...